Home

Epidemiology of syphilis

Syphilis is a bacterial infection transmitted by sexual contact and is believed to have infected 12 million people in 1999 with greater than 90% of cases in the developing world. It affects between 700,000 and 1.6 million pregnancies a year, resulting in spontaneous abortions, stillbirths, and congenital syphilis Syphilis, a genital ulcerative disease caused by the bacterium Treponema pallidum, is associated with significant complications if left untreated and can facilitate the transmission and acquisition of HIV infection. 1-3 Additionally, historical data demonstrate that untreated syphilis in pregnant women, if acquired during the four years before delivery, can lead to infection of the fetus in up to 80% of cases and may result in stillbirth or infant death in up to 40% of cases.

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages Syphilis is a sexually transmitted infection caused by Treponema pallidum subspecies pallidum and may lead to severe complications. Recent years have seen striking increases in syphilis in many countries This paper extends this descriptive epidemiology of syphilis in three ways. Firstly, we conduct a systematic review of countries with published antenatal syphilis prevalence (ASP) estimates from pre-1952 till the present

Epidemiology In the late 1990s, the prevalence of syphilis plummeted in many countries with endemic syphilis, largely thought to be due to the introduction of syndromic management for STIs [ 51, 52 ], behavioral changes, and the effect of AIDS mortality disrupting sexual networks [ 53, 54, 55 ] STI Prevalence, Incidence, Cost Estimates in the United States (January 25, 2021) STD Surveillance 2019 - Syphilis (April 13, 2021) Figures. ppt icon. Tables. STD Health Equity. Primary and Secondary Syphilis — Distribution of Cases by Sex and Sex of Sex Partners, United States, 2019. Image Source: STD Surveillance 2019 SUMMARY Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described in 1905, but because of the inability to culture the organism and the. Syphilis Is a Chronic, Infectious Disease, Over the centuries, Europeans have had to contend with four pox diseases: chickenpox, cowpox, smallpox, and the Great Pox, the latter now known as syphilis. The first European epidemic was recorded in the late 1400 s, shortly after the conquest of Naples by the French army

Syphilis is an infectious venereal disease caused by the spirochete Treponema pallidum. Syphilis is transmissible by sexual contact with infectious lesions, from mother to fetus in utero, via blood.. The epidemiology of syphilis had been declining after the introduction of penicillin [ 27 ]. Syphilis has got more attention after the emergence of HIV/AIDS as they share the common route of transmission. As a result, syphilis interventions are given along with HIV prevention In 2017, 33 189 confirmed syphilis cases were reported in 28 EU/EEA Member States. Reported syphilis rates were nine times higher in men than in women and peaked among 25-34-year-old men. Two-thirds of syphilis cases with information on transmission category were reported in men who have sex with men (MSM) CONCLUSIONS: Syphilis prevalence in the general population in Kenya is relatively low and eradication could be possible but would require intensified syphilis prevention and control efforts, including routine screening in HIV, sexually transmitted infection and antenatal care clinics as well as in family planning and male circumcision settings

Epidemiology of syphilis - Wikipedi

  1. Further information on the epidemiology of infectious syphilis is available in the the Kirby Institute HIV, viral hepatitis and sexually transmissible infections in Australia: a nnual survelliance report
  2. Objectives: This study aims to analyze the epidemiology of syphilis, gonorrhea and genital chlamydial infections in Romania during 1980-2009 when radical changes occurred during transition from a communist regime to a democratic society. Methods: Surveillance data was retrieved from the National Center for Surveillance and Control of the Communicable Disease in Romania and the World Health.
  3. The following summarizes syphilis epidemiology in the United States based on specific demographics features per the 2019 CDC STD Surveillance report. Sex: In 2019, the rate of reported primary and secondary syphilis cases among males (20.1 cases per 100,000 males).
  4. The epidemiology of this first syphilis epidemic shows that the disease was either new or a mutated form of an earlier disease. Some researchers argue that syphilis was carried from the New World to Europe after Columbus' voyages, while others argue the disease has a much longer history in Europe
  5. An epidemic in one population can be masked by a similar decline in a similar-size population or by a much smaller decline in a much larger population. This phenomenon has occurred repeatedly with syphilis. Fig. 1: Primary and secondary syphilis rates, United States, 1941-2003

Syphilis is an infection caused by the bacterium Treponema pallidum. Most new cases of syphilis are sexually acquired. The clinical manifestations depend upon the stage of disease. Studies performed in the pre-antibiotic era permit a relatively complete understanding of the natural history of untreated syphilis Epidemiology of Syphilis* THEODORE J. BAUER, M.D. and ALBERT P. ISKRANT, M.A. Washington, D. C. CASE finding is of first importance in syphilis control. It is the process which must be fulfilled before treat- ment which leads to the ultimate objective, control, can be effected

Syphilis - 2018 Sexually Transmitted Diseases Surveillanc

  1. Molecular Epidemiology of Syphilis Sexually Transmitted Diseases Volume 37, Number 10, October 2010 661. T. pallidum subtype 14d9 was detected in 52 of 69 fully subtyped specimens (75%; 95% confidence interval [CI], 64%-.
  2. Syphilis is a chronic infectious disease with three stages caused by Treponema pallidum. Epidemiology of Syphilis Europe and USA: Declining frequency, the incidence of syphilis dropped in the last decades from 20/100000 to 3-5/100000 for primary and secondary syphilis. Since 2000 rising incidence, especially in risk groups for syphilis: young.
  3. Serological markers of lifetime syphilis (treponemal test) were detected in 2.5% (95% CI: 1.6-3.6) of participants, and active syphilis (treponemal test and VDRL) present in 1.2%. No samples were positive for anti-HCV. The prevalence of lifetime HBV infection (current or past infection) was 15.9%, and 0.7% (95% CI 0.4 to 1.5) were HBsAg-positive

The incidence of congenital syphilis has been increasing since 2009.16, 17 Most newborns with congenital syphilis (60% to 90%) are asymptomatic at birth.16, 18 From birth to 48 months of age. Syphilis is a bacterial infection caused by sexual contact [2] and is believed to have infected 12 million people in 1999 with greater than 90% of cases in the developing world. [3] It affects between 700,000 and 1.6 million pregnancies a year, resulting in spontaneous abortions, stillbirths, and congenital syphilis. [4] In Sub-Saharan Africa syphilis contributes to approximately 20% of. Countries can also work to reduce syphilis prevalence across populations, by ensuring that testing, treatment and partner referral for the infection are put into action, beyond that of antenatal care. The importance of syphilis surveillance towards the goal of congenital syphilis elimination Syphilis is a sexually transmitted disease caused by Treponema pallidum, with human beings as the only host. Syphilitic infection of the nervous system results in the most chronic, insidious.. Syphilis is a primarily sexually transmitted disease caused by the spirochete Treponema pallidum. The prevalence of syphilis varies widely around the world. Early syphilis affects approximately 50 people per 100,000 in the United States and Western Europe but 200 to 500 people per 100,000 in Africa and Latin America

In 2012, the prevalence of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide. The incidence and prevalence of syphilis may be affected by age, gender, race, sexual behavior and geographical distribution. Epidemiology Incidence. Worldwide incidence of syphilis In China, where syphilis was virtually eradicated in the 1950s, both the incidence and prevalence of the disease have more than quadrupled from the 1990s to the 2010s. Tucker JD, Cohen MS. China's syphilis epidemic: epidemiology, proximate determinants of spread, and control responses Epidemiology. Syphilis is caused by a spirochete organism, Treponema Pallidum, which has a thin, slow-moving, corkscrew-like body. Other variants of this family of Treponematoses include Treponema pertenue (yaws), Treponema endemicum (bejel), and Treponema carateum (pinta). Venereal syphilis is thought to have mutated from yaws by many. 2017-5-4 Syphilis: Epidemiology, pathophysiology, and clinical manifestations in HIV-uninfected patients - UpToDate Official reprint from UpToDate® www.uptodate.com ©2017 UpToDate® Syphilis: Epidemiology, pathophysiology, and clinical manifestations in HIV­uninfected patients Authors: Charles B Hicks, MD, Meredith Clement, MD Section Editor: Noreen A Hynes, MD, MPH, DTM&H Deputy Editor.

The history and epidemiology of syphilis This edition was published in 1933 by C.C. Thomas in Springfield, Ill, . Baltimore, Md. Edition Notes Lectures delivered under the Adolph Gehrmann endowment, University of Illinois, College of Medicine, Chicago, March 1, 2 and 3, 1933. Series The Gehrmann lectures, University of Illinois. Objectives The authors used data from the Kenya AIDS Indicator Survey (KAIS) 2007 to determine the prevalence of syphilis and associated risk factors among adults aged 15-64 years. Methods KAIS was a nationally representative population-based sero-survey that examined demographic and behavioural indicators and serological testing for syphilis, HIV and herpes simplex virus type 2 (HSV-2) in. From about the middle of the 19th century to the middle of the 20th century the incidence of syphilis in developed countries declined, except in times of war. During each of the World Wars, the Korean war and the Vietnam War, the incidence of syphilis, and STD's in general, rose sharply but only briefly

Genomic epidemiology of syphilis reveals independent

  1. Epidemiology of syphilis. Globally, T. pallidum subsp. pallidum (T. pallidum) is the most significant pathogen of the genus Treponema.Infection is usually transmitted through contact with an active lesion of a sexual partner (acquired syphilis) or from an infected pregnant woman to her fetus (congenital syphilis)
  2. The incidence of congenital syphilis has been increasing since 2009.16, 17 Most newborns with congenital syphilis (60% to 90%) are asymptomatic at birth.16, 18 From birth to 48 months of age.
  3. Syphilis is an important public health issue worldwide. The World Health Organization has estimated that there are 5.6 million new cases of syphilis globally each year [], and global prevalence is estimated to be 56.1 million [].In the United States alone, syphilis incidence has more than tripled since 2000 [].Congenital syphilis rates in the US have also increased and are currently the.

Objective: To describe the epidemiology of infectious syphilis among Aboriginal and Torres Strait Islander (Indigenous) people in Australia. Design and setting: We assessed trends in national infectious syphilis notification rates from 2005 to 2009 using Poisson regression, with a focus on geographic and demographic differences by Indigenous status. We compared Indigenous and non‐Indigenous. epidemiology to describe differences, variations and disproportions in the health status of individuals or groups. It is a descriptive term. No value judgment is necessarily implied. Adapted from: 1) Kawachi,I., Subramanian, S., & Almeida-Filho (2002). A glossary for health inequalities. Journal of Epidemiology and Community Health: 56: 647 -65 The annual incidence of syphilis, gonorrhea and genital chlamydial infections in Romania were calculated by using all cases reported for each year divided by the total population as provided by the Romanian Census Bureau. 7 Age, sex, and rural versus urban inhabitance specific annual incidence were also calculated for selected periods of time. In communities and populations in which the prevalence of syphilis is high and in women at high risk of infection, serologic testing should also be performed twice in the third trimester (ideally at 28-32 weeks gestation) and at delivery. 19 Syphilis screening also should be offered at sites providing episodic care to pregnant women at high. It remains to be determined whether COVID-19 will have lasting effects on the epidemiology of syphilis and other STIs. The spread of SARS-CoV-2 may change the epidemiology of STIs and may also raise concerns about sexual intimacy that will have to be considered when counselling patients

The Global Epidemiology of Syphilis in the Past Century

  1. The estimated prevalence and incidence of syphilis varies substantially by region or country, with the highest prevalence in Africa and >60% of new cases occurring in LMICs 27
  2. Abstract. Objective: To describe the epidemiology of infectious syphilis among Aboriginal and Torres Strait Islander (Indigenous) people in Australia. Design and setting: We assessed trends in national infectious syphilis notification rates from 2005 to 2009 using Poisson regression, with a focus on geographic and demographic differences by Indigenous status
  3. The epidemiology of syphilis varies across health regions in Virginia. The Eastern and entral regions of the state experience the greatest burden of syphilis in terms of both case counts and rates (Figure 5), with most cases concentrated in more urban areas
  4. For symptoms and general information on syphilis, visit NHS.UK. Data collection and epidemiology From 2020, the surveillance of congenital syphilis has become part of the Infectious Diseases in.
  5. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016 Jane Rowley a, Stephen Vander Hoorn b, Eline Korenromp c, Nicola Low d, Magnus Unemo e, Laith J Abu-Raddad f, R Matthew Chico g, Alex Smolak f, Lori Newman h, Sami Gottlieb a, Soe Soe Thwin a, Nathalie Broutet a & Melanie M Taylor a. a. Department of Reproductive Health and Research, World.
  6. Louisiana Office of Public Health -Infectious Disease Epidemiology Section -Annual Report 2008 _____ Page 1 of 5 Syphilis (Primary & Secondary) Syphilis is a Class B Disease and must be reported to the state within one business day. Syphilis is an acute and chronic disease caused by the Treponema pallidum bacteria. The primar

An Update on the Global Epidemiology of Syphilis

Syphilis Statistics - STD information from CD

Details. Analyses of syphilis epidemiology in England, collated by Public Health England ( PHE) are presented here. The PHE Syphilis Action Plan published in June 2019 brings together the existing. The incidence of syphilis decreased significantly with the introduction of penicillin in the 1940s but rose sharply again with the advent of human immunodeficiency virus (HIV) infection in the 1980s To our knowledge, this is the first systematic review and meta-analysis assessing global syphilis prevalence among MSM. The number of MSM tested in published studies has increased between 2000 and 2020. While the global syphilis prevalence among MSM was 7·5% over 20 years, SDG regional estimates ranged from 1·9% to 10·6% Syphilis is caused by the spirochete bacterium Treponema pallidum and can be transmitted both sexually and from mother to child. T pallidum can infect any organ and produces a clinical disease with a relapsing and remitting course. It is not hard to see, therefore, why it is often described as the great mimic. In this review, we provide an update of modern syphilis epidemiology, clinical.

The global pooled prevalence of syphilis among men who have sex with men was 7.5 per cent during 2000-2020 (95 per cent CI: 7.0-8.0), as compared to the most recent estimate of syphilis among men. Congenital syphilis is a devastating disease that is responsible for between 20% and 30% of perinatal deaths in Sub-Saharan Africa [2]. Passed from an infected mother to her growing fetus, syphilis manifests itself in the newborn in much the same way it does in the adult: in three stages of increasing severity CONCLUSIONS: Syphilis remains a significant problem in the United States, and its epidemiology is influenced by a complex combination of factors. To prevent and control syphilis effectively, public health practitioners must understand these factors and design programs and interventions that address the disease in the context of these factors Syphilis spreads from person to person via skin or mucous membrane contact with these sores. After the initial infection, the syphilis bacteria can remain inactive (dormant) in your body for decades before becoming active again. Early syphilis can be cured, sometimes with a single shot (injection) of penicillin

Syphilis: Review with Emphasis on Clinical, Epidemiologic

  1. ation and violence; improve sexuality education, and expand access and delivery of syphilis testing and immediate treatment for all populations at higher.
  2. The interaction with HIV co-infection, changes in sexual behaviour following wider availability of effective antiretroviral HIV treatment, the changing means and ease of finding sexual partners as a consequence of Internet and mobile dating applications have increased the complexity of the syphilis epidemiology, and particularly its control
  3. Latin America and the Caribbean region had the highest prevalence of syphilis (10.6%), whereas Australia and New Zealand had the lowest (1.9%). There is, therefore, an urgent need to quantify the.
  4. Prevalence, Background information, Syphilis, CKS. Globally — the World Health Organisation (WHO) estimated that globally in 2012 []: . In people aged 15-49 years of age: There were 5.6 million new cases of syphilis — an incidence rate of 1.5 per 1000 females and 1.5 per 1000 males
  5. Epidemiology o infected 12 million people in 1999 . 90% of cases in thedeveloping world. o affects 700,000 - 1.6 million pregnancies a year. spontaneous abortions, stillbirths, and congenital syphilis. o Sub-Saharan Africa -20% of perinatal deaths. o Since 2000, rates of syphilis have been increasing in the US, UK, Australia and Europe.

Syphilis: Agent, Epidemiology, Symptoms, Treatment and

In fact, the prevalence of syphilis among men who have sex with men was 7.5 percent, while for the general population it is 0.5 percent. Additional investigation found that more men had syphilis in locations that also had a high HIV prevalence. Prevalence was found to be higher between 2015 and 2020 than the five years prior to that period Background. Syphilis is a disease caused by bacteria called Treponema pallidum . Major rout of transmission of this bacterium was through sexual and contact with mucocutaneous lesion. Untreated syphilis during pregnancy can greatly affect pregnancy outcome, resulting in spontaneous abortion and stillbirth. Objective. The objective of the study was to determine the seroprevalence of syphilis. Objective . Syphilis is one of the most imperative STIs, caused by the spirochete Treponema pallidum . During pregnancy it is associated with disastrous health outcomes in the newborn. In sub-Saharan Africa, study findings on the prevalence of syphilis among pregnant women are highly dispersed and inconsistent. The aim of the current review is to conduct a systematic review and meta-analysis.

Similar Items. Syphilis as a modern problem / by: Pusey, William Allen, 1865-1940. Published: (1915) The modern treatment of syphilis / by: Moore, Joseph Earle, 1892- Published: (1933) A treatise on syphilis, historical and practical / by: Lancereaux, Etienne, 1829-1910 The incidence of APOs and the hazard ratios of associated predictors using Cox proportional hazard model. Results. Syphilis treatment data were available from 83.86% of diagnosed women. Including deliveries from the total study population, 13.33% experienced APOs We asked Jennifer Mahn, MPA, associate director of clinical programs at the National Coalition of STD Directors (NCSD), if it will influence the incidence of congenital syphilis. Jennifer Mah Introduction. Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, is frequently encountered amongst human immunodeficiency virus (HIV)-infected individuals.The prevalence of co-infection with HIV and syphilis varies from 8% to 25%, 1,2 depending on the prevalence of both infections within the community and the group of patients studied

Syphilis: Background, Pathophysiology, Etiolog

Syphilis is a sexually transmitted infection (STI) caused by the Treponema pallidum spirochete. This study was aimed to determine the prevalence of Syphilis among pregnant women attending State Specialist Hospital Maiduguri. Out of one hundred an The incidence rate of primary and secondary syphilis was 16.9 cases in 100,000 men in 2017, and 2.3 cases in 100,000 women. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance, 2017 Syphilis in the United States: National Trends and Epidemiology Sarah Kidd, MD, MPH Medical Epidemiologist Surveillance Team Division of STD Prevention Centers for Disease Control and Prevention California Syphilis Prevention Summit January 10, 2017. 0 10 20 30 40 50 60 70 80 Year Primary and Secondary Syphilis —Rate of Reported Cases The Syphilis epidemiology segment covers the epidemiology data in the US, EU5 countries (Germany, Spain, Italy, France, and the UK), and Japan from 2017 to 2030. It also helps to recognize the causes of current and forecasted trends by exploring numerous studies, survey reports and views of key opinion leaders Syphilis, a sexually transmitted disease, has resurged since the new millennium. Treponema pallidum subsp. Pallidum (T. pallidum), the etiologic agent of syphilis, can attack any human organs, including the central nervous system (CNS). The interaction between T. pallidum and the human body is a complex mechanism. Once infected with T. pallidum, human hosts mount robust cellular and humoral.

Syphilis. Syphilis is caused by a bacteria through sexual contact with an infected person. Transmission can also occur through blood transfusion if the donor is in the early stages of the disease, or by sharing needles with an infected person. Pregnant women can pass the infection to their unborn babies Incidence of syphilis in the United States: From 2005 to 2014, the incidence of primary and secondary syphilis increased from 2.9 to 6.3 cases/100,000/year. From 2009 to 2014, the incidence of late and latent syphilis increased from 5.6 to 7.4 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014

Epidemiology. Infectious syphilis (primary, secondary and early latent stages) is the third most common nationally notifiable bacterial sexually transmitted infection (STI) in Canada. The rate of infectious syphilis continues to increase in Canada. Gay, bisexual and other men who have sex with men (gbMSM) are disproportionately affected epidemiology of syphilis in Ethiopia needs to be better characterized. A well organized and synthesized data on the epidemiology of syphilis may help to define target points for syphilis control efforts and thus may help to target interventions to make people towards the elimin-ation of syphilis. It may also help to establish baselin Syphilis is one of the sexually transmitted diseases that is prevalent in developing countries and is of public health importance. Among pregnant women, it is reported to cause foetal defects if not treated. This study was thus carried out to determine the prevalence of syphilis among pregnant women visiting a health facility in Rivers State Tertiary syphilis ; Tertiary syphilis is responsible for a majority of the morbidity and mortality associated with the disease. The hallmark of tertiary syphilis is the destruction of tissue caused by a response to the presence of treponemal antigens. The three most common forms are neurosyphilis, cardiovascular syphilis and gummatous syphilis Office of Sexual Health and Epidemiology . Sexually Transmitted Infection Descriptions: Syphilis. Syphilis. 3. is an STI caused by the bacterium . Treponema pallidum

The epidemiology of syphilis in Ethiopia: a protocol for

Syphilis is mainly spread through sexual contact and blood. The incidence of syphilis is high among drug users. Methadone maintenance treatment (MMT) clinics have been implemented in China since 2004. The aim of this study was to estimate the prevalence and risk factors of syphilis among drug users at MMT clinics in China between 2004 and 2013 Primary and Secondary Syphilis, Cases and Incidence Rates, California Counties and Selected City Health Jurisdictions, 2014-2018. 2014 2015 2016 2017 201 Nationally, an infectious syphilis outbreak case is defined as: any person who is newly diagnosed with confirmed or probable infectious syphilis according to the CDNA national surveillance case definition for infectious syphilis, OR, is a sexual contact of a confirmed outbreak case (category 2 outbreak cases)

Video: Syphilis - Annual Epidemiological Report for 201

Sexually transmitted bacterial diseases - online presentationSyphilis epidemiology and demographics - wikidocCongenital Syphilis: A Discussion of EpidemiologySyphilis infection - Images | BMJ Best Practice

Epidemiology of syphilis in Kenya: results from a

6. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia . Background: The study aims to examine the trends of syphilis infection in Victoria and the characteristics of notified cases of syphilis among different population group response to syphilis treatment.Syphilis may also have a negative impact on the HIV viral load. This topic will review the epidemiology, clinical presentation, diagnosis, and treatment of syphilis in patients latent syphilis cases. A more detailed discussion of latent syphilis is presented elsewhere. The diagnosis of syphilis is made in the same fashion whether or not an individual is. In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiology of HIV, syphilis, and hepatitis B (HBV) and hepatitis C viruses (HCV), and to evaluate immunization coverage against hepatitis B in a group of rural workers in Brazil The World Health Organization Global Health Sector Strategy aims to reduce worldwide syphilis incidence by 90% between 2018 and 2030. To achieve this goal, interventions that target high-burden groups, including MSM, will be required. However, there are no global prevalence estimates of syphilis among MSM to serve as a baseline for monitoring or modelling disease burden

HIV/AIDS Dermatological Images - HIVPPT - Infectious Disease Epidemiology PowerPointTreatment of Syphilis | HIV | JAMA | The JAMA NetworkTabes dorsalis - Wikipedia

Five cases of prostate cancer (person-years = 706) were reported among men with a history of syphilis, and 2,049 cases (person-years = 299,582) were reported among men without such a history (age-adjusted RR, 1.06; 95% CI, 0.44-2.59). The reported cumulative incidence of syphilis was too low to perform additional analyses. Clinical Prostatiti The initial prevalence, the incidence during pregnancy and the overall prevalence of syphilis at delivery were 0.9%, 0.4% and 1.3% respectively. Risk factors for syphilis during pregnancy were younger age for the incidence and older age and a history of stillbirth for the prevalence. Women with syphilis during pregnancy had significantly more. A World Health Organisation (WHO) study has highlighted an unacceptably high global prevalence of syphilis among men who have sex with men. The world body, in the new study on Prevalence of syphilis among men who have sex with men: A global systematic review and meta-analysis from 2000 to 2020'' also emphasised ways to eliminate the infection Prevalence of the syphilis (3.1%) in the Punjab population is high as compared to Indian population (1.7%) . In china the prevalence found to be 0.47% among the blood donors form 2000-2010 . A recently a paper reported high prevalence of syphilis (5.7%) in the blood donors in Edea, Cameroon. In 2004 National AIDS control program carried out a. Syphilis is a sexually transmitted disease (STD), which is spread by having unprotected vaginal, anal or oral sex. It can also be spread from mother to baby during pregnancy. Syphilis has been called the great imitator because its symptoms are similar to other infections and diseases Syphilis prevalence estimates were calculated at country level before aggregating for regional and global estimates. All reported data were adjusted for laboratory test to approximate the prevalence of probable active infections, defined as having positive serology on both treponemal and non-treponemal tests . We assumed that the.