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Grading of soft tissue sarcoma

Grading of soft tissue sarcomas: the challenge of

Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world Histopathology. 2006 Jan;48(1):42-50. doi: 10.1111/j.1365-2559.2005.02288.x. Authors A T Deyrup 1 , S W Weiss. Affiliation 1 Department of Pathology and. Soft tissue sarcomas (STSs) represent a heterogeneous group of rare malignant tumors with a wide spectrum in terms of histologic type and prognosis.1 Histologic classification has some limitations and is not very convenient for patient care. It is complex and subject to periodical variations, and its reproducibility is relatively poor among pathologists who are not familiar with soft tissue. There are 4 grades for sarcoma: GX (the grade cannot be evaluated), G1, G2, and G3. In general, the lower the tumor's grade, the better the prognosis. Sarcomas, Soft Tissue . Introduction. Statistics. Medical Illustrations. Risk Factors. Symptoms and Signs. Diagnosis. Stages and Grades. Types of Treatment. About Clinical Trials Several histological grading systems for soft tissue sarcomas have been described since the early 1980s. Their main objective is to select patients for adjuvant chemotherapy. Two histological grading systems are used in daily practice, the National Cancer Institute (NCI) and the French Federation of Cancer Centers Sarcoma Group (FNCLCC) systems Histological diagnosis and grading of soft-tissue sarcomas. Leyvraz S(1), Costa J. Author information: (1)Cancer Center, University of Lausanne, Switzerland. Grading methodology for soft-tissue tumors is not yet unequivocally established. The authors use a system that is an elaboration upon that of the National Cancer Institute: grade 1 or low.

The grade is part of the stage for a soft tissue sarcoma. It tells you how much the cancer cells look like normal cells, how fast they are growing, and how much of the tumor has cells that are dying Background: Treatment decisions for multimodal therapy in soft tissue sarcoma (STS) patients greatly depend on the differentiation between low-grade and high-grade tumors. We developed MRI-based radiomics grading models for the differentiation between low-grade (G1) and high-grade (G2/G3) STS Grading of malignant peripheral nerve sheath tumor, embryonal and alveolar rhabdomyosarcoma, angiosarcoma, extraskeletal myxoid chondrosarcoma, alveolar soft part sarcoma, clear cell sarcoma and epithelioid sarcoma is not recommended (Cancer 1984;53:530) The case for grading malignant peripheral nerve sheath tumor is currently being debate

Stage I soft tissue sarcomas are low-grade tumors of any size. Small (less than 5 cm or about 2 inches across) tumors of the arms or legs may be treated with surgery alone. The goal of surgery is to remove the tumor with some of the normal tissue around it BACKGROUND: Treatment decisions for multimodal therapy in soft tissue sarcoma (STS) patients greatly depend on the differentiation between low-grade and high-grade tumors. We developed MRI-based radiomics grading models for the differentiation between low-grade (G1) and high-grade (G2/G3) STS. METHODS: The study was registered at ClinicalTrials. Soft tissue sarcomas are graded from G1 to G3, with higher grade sarcomas having a greater likelihood of growing and spreading at a faster and more aggressive rate than lower grade sarcomas. The soft tissue sarcoma staging process involves several values, including: T (tumor): describes the size of the original tumor. T1 means the tumor is 5 cm. The pathologist usually gives soft tissue sarcoma a grade from 1 to 3. A lower number means the cancer is a lower grade. There are several different grading systems used for soft tissue sarcoma and some of them have 2 or 4 grades instead of 3 grades. Low-grade cancers have cancer cells that are well differentiated A high grade cancer is likely to be faster growing and is more likely to spread than a low grade sarcoma. The grade is one of the things your doctors need to know to work out the stage of your sarcoma. Staging systems. There are different systems used in the UK to stage soft tissue sarcoma. The two main ways are the TNM system and number systems

Soft Tissue Sarcoma - Fitzpatrick Referrals

Grading of Soft Tissue Sarcomas: Review and Update

Soft tissue sarcoma of the head and neck is a new classification and anatomic staging and prognostic groups have not yet been defined due to a lack of data. The TNM and G classifications are provided in Tables 2 and 3 below. [ 2] Table 2. TNM Classification for Soft Tissue Sarcoma of the Head and Neck (Open Table in a new window Considerable changes in the clinical and pathologic staging of soft tissue sarcoma (STS) are presented in the 8th edition of the AJCC Cancer Staging Manual. 1 There are some obvious improvements, such as the creation of separate staging schemes for different anatomic locations. It is well-known that STSs arising within the extremities or trunk, retroperitoneum or abdominopelvic cavities, or.

Sarcomas, Soft Tissue: Stages and Grades Cancer

Grading of soft tissue sarcomas: from histological to

The Grading of Soft Tissue Sarcomas Results of a Clinicohistopathologic Correlation in a Series of 163 Cases JOSE COSTA,' R. A. WESLEY,t E. GLATSTE1N.S AND S. A. ROSENBERGS A multidisciplinary study of 163 patients treated at the NCI for soft tissue sarcomas allowed the correlation of a number of histologic features (histologic type, mitosis, necrosis, pleomorphism, cellularity, an Haemangiopericytomas, which show absence of current management strategies, the grade of soft tissue necrosis, absence of haemorrhagic areas and mitotic sarcoma plays an important role in deciding the therapy figures less than one per 10 high power fields. and prognosis of sarcomas.1,7,8 There are only limited 5

Histological diagnosis and grading of soft-tissue sarcomas

Summary: Several histological grading systems for soft tissue sarcomas have been described since the early 1980s. Their main objective is to select patients for adjuvant chemotherapy. Two histological grading systems are used in daily practice, the National Cancer Institute (NCI) and the French Federation of Cancer Centers Sarcoma Group (FNCLCC) systems The aim of this study is to develop a predictive radiomics model for tumor grading determination. Condition or disease. Sarcoma, Soft Tissue. Detailed Description: Soft tissue sarcomas (STS) constitute an overall rare malignant entity comprising 1% of all cancers with a yearly incidence rate of 3.8 per 100.000 inhabitants

Purpose: The aim of the study was to investigate the feasibility of 18F-3′-fluoro-3′-deoxy-l-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS). Experimental Design: Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET Considerable changes in the clinical and pathologic staging of soft tissue sarcoma (STS) are presented in the 8th edition of the AJCC Cancer Staging Manual. 1 There are some obvious improvements, such as the creation of separate staging schemes for different anatomic locations. It is well-known that STSs arising within the extremities or trunk, retroperitoneum or abdominopelvic cavities, or. Two systems for grading soft tissue sarcoma are widely used currently: the Pediatric Oncology Group and the Fédération Nationale des Centers de Lutte Contre le Cancer systems. In this study, we demo..

Histological grade for soft tissue sarcomas reported in the clinical data analyzed in this study utilized the National Cancer Institute (NCI) grading scheme which depends on the number of mitoses. Histologic grading has been considered the most important prognostic factor for soft tissue sarcomas. Several grading systems have been proposed based on the assessment of morphologic features in heterogeneous groups of sarcomas. Currently, th Background. Treatment decisions for multimodal therapy in soft tissue sarcoma (STS) patients greatly depend on the differentiation between low-grade and high-grade tumors. We developed MRI-based radiomics grading models for the differentiation between low-grade (G1) and high-grade (G2/G3) STS Jan C. Peeken, Matthew B. Spraker, Carolin Knebel, Hendrik Dapper, Daniela Pfeiffer, Michal Devecka, Ahmed Thamer, Mohamed A. Shouman, Armin Ott, Rüdiger von. The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases. Cancer. 1984 Feb 1. 53 (3):530-41. . American Joint Committee on Cancer. Soft Tissue.

In the eighth edition, bone sarcomas and soft tissue sarcomas are described according to primary tumor site for the first time. The specific criteria depending on tumor site is made for T factor. Some improvements are also noted, such as the histologic grades of both bone and soft tissue sarcomas becoming a three-grade classification Table 2 Soft-tissue sarcoma grading system (Kuntz 1997) Histopathology grade. For soft-tissue sarcomas, it is important that a microscopic description be requested along with a diagnosis as this information is used to assign the tumor a grade. Tumors can be divided into low-, intermediate- and high-grade tumors based on histologic features such. Chapter 33 Soft Tissue Sarcomas Samuel Singer DISTRIBUTION, AGE, AND CAUSES MOLECULAR GENETICS EVALUATION HISTOLOGIC GRADING AND PROGNOSTIC FACTORS FOR OUTCOME STAGING MANAGEMENT SUMMARY Soft tissue sarcomas are rare and unusual neoplasms, accounting for approximately 1% of adult human cancers and 15% of pediatric malignancies. Sarcomas affect more than 10,600 patients/year in the United State

There are different staging systems for the different types of soft tissue sarcoma. So, your doctor is the best source for an explanation of your particular soft tissue sarcoma staging. There are four general soft tissue sarcoma stages based on tumor size and grading groupings: Stage I: The tumor is small and GX or G1 INTRODUCTION. Sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies and 12 percent of pediatric cancers [].Approximately 80 percent of new cases of sarcoma originate from soft tissue, and the rest originate from bone [].The histopathologic spectrum of sarcomas is broad, presumably because the embryonic.

Soft Tissue Sarcoma Stages & Grading Explaine

  1. Introduction. Sarcomas are a large, diverse group of malignant tumors of mesenchymal origin. The World Health Organization (WHO) divides sarcomas into two broad categories: sarcomas of soft tissue and sarcomas of bone ().Soft-tissue sarcomas affect all ages and may arise at any location in the body
  2. All soft-tissue sarcoma subtypes are included, except desmoid tumors (deep fibromatosis), Kaposi sarcoma, and infantile fibrosarcoma. In keeping with the FNCLCC (Fédération Nationale des Centres de Lutte Contre la Cancer) sarcoma grading system, three distinct histologic grades are recognized, based on the degree of differentiation.
  3. the grading of all tumors. In this study, soft tissue sarcomas were classified into six histologic types: ma-lignant fibrous histiocytoma (MFH), liposarcoma, sy-novial sarcoma, spindle cell sarcoma, small round cell sarcoma, and others. The histologic grade is a three-grade system obtained by adding the scores for tumo
  4. High grade: In high-grade soft tissue sarcoma, the cancer cells look more abnormal under a microscope and grow and spread more quickly than in low-grade and mid-grade soft tissue sarcoma. For adult soft tissue sarcoma of the trunk, arms, and legs, the following stages are used: Stage I. Stage I adult soft tissue sarcoma of the trunk, arms, and.
  5. Low-grade soft tissue sarcomas have little metastatic potential, but they have a propensity to recur locally. Accordingly, surgical excision with negative tissue margins of 1 cm to 2 cm or larger in all directions is the treatment of choice for patients with these early-stage sarcomas..
  6. histologic diagnosis but also a grade in the instance of a soft tissue sarcoma (grade has prognostic significance and can alter treatment decisions). When a biopsy is performed for the purpose of obtaining a grade, it is important to remember that it is 59% accurate, with underestimating the grade in most cases where it lacks accuracy
  7. Adult soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. The soft tissues of the body include the muscles, tendons (bands of fiber that connect muscles to bones), fat, blood vessels, lymph vessels, nerves, and tissues around joints. Adult soft tissue sarcomas can form almost anywhere in the body, but are most common in the head, neck, arms.

The revised AJCC Cancer Staging Manual, Eighth edition classifies soft tissue sarcoma based on TNM and tumor grade (G).{ref1} The AJCC follows the grading system of the French Federation of Cancer. A soft-tissue sarcoma (STS) is a malignant tumour, a type of cancer, that develops in soft tissue. A soft tissue sarcoma is often a painless mass that grows slowly over months or years. They may be superficial or deep-seated. Any such unexplained mass must be diagnosed by biopsy. Treatment may include, surgery, radiotherapy, chemotherapy, and targeted drug therapy On the whole, the outlook following treatment for soft tissue sarcomas is better than feared, especially bearing in mind this is a malignant cancer. For average sized grade 1 and 2 soft tissue sarcomas, treated with surgery and possibly radiation therapy, approximately three-quarters of patients will be alive three years later In pathology, grading is a measure of the cell appearance in tumors and other neoplasms.Some pathology grading systems apply only to malignant neoplasms (); others apply also to benign neoplasms. The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the resemblance of the tumor to the tissue of origin The outlook for a soft tissue sarcoma mostly depends on the type of sarcoma it is, how likely it is to spread (the grade) and how far it has already spread (the stage) by the time it's diagnosed. If it's detected at an early stage or is a low-grade tumour and it can be removed during surgery, a cure is usually possible

Tumor grading of soft tissue sarcomas using MRI-based

  1. Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies that have a high rate of recurrence and mortality. Outcomes in patients with high-grade STS are substantially improved by treatment with neoadjuvant radiotherapy and/or chemotherapy [1,2,3,4,5,6]; therefore, histological type and grade are important prognostic factors that guide STS treatment decision-making [7,8,9,10,11,12]
  2. Soft Tissue Sarcoma Overview. Soft tissue sarcoma refers to cancer that begins in the muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body. The tumors can be found anywhere in the body but often form in the arms, legs, chest, or abdomen. Signs of soft tissue sarcoma include a lump or swelling in soft tissue
  3. Soft tissue sarcoma is a generic name utilized for several types of cancers which affect an array of tissues. Under this umbrella group, there are tumors that arise both from the subcutaneous connective tissue and the skin per se. The cancer can affect the fat (liposarcoma), the nerves (Schwannoma, neurofibrosarcoma, malignant peripheral nerve.
  4. Soft tissue sarcoma in dogs (STS) is a group of malignant tumors that originate from connective tissue below the skin. They make up approximately 15% of all skin tumors in dogs. Most occur as a single tumor, usually in middle to older dogs and can occur anywhere in the body. Sarcomas appear on or underneath the skin
  5. Soft tissue sarcoma is a rare cancer that begins in the soft tissues of the body. Examples of soft tissue include fat, muscles, nerves, tendons, and blood and lymph vessels. Soft tissues can also be contained within organs. Sarcoma can happen in soft tissue anywhere in the body, but 40 percent occur in the arms and legs
  6. al soft tissue sarcoma, and tumor types known to have a higher rate of metastasis

Pathology Outlines - Gradin

  1. Dogs with grade V soft tissue sarcoma have the lowest life expectancy. However, other factors will influence the ability for the dog to recover, including underlying or secondary health problems. Since soft tissue sarcoma in dogs is most common in older or senior dogs , it is possible palliative treatment will be implemented
  2. Dog Soft Tissue Sarcoma Life Expectancy. The life expectancy of dogs that have soft tissue sarcoma depends mostly on the grade of the tumor. The good news is that, with treatment, there's only about a 20% chance that a low to intermediate-grade sarcoma will spread to surrounding organs. The outlook isn't so bright for high-grade sarcomas
  3. Soft Tissue Sarcoma Treatment: After accurate diagnosis, staging, and multidisciplinary team review, treatment may begin. Treatment plans are derived from tumor anatomic location, sarcoma subtype, tumor grade and staging. In general, soft tissue sarcomas are often treated with radiation and surgery for tumor removal and local control
  4. Low-grade soft tissue sarcomas are less likely to spread. Low-grade sarcomas contain cells that more closely resemble normal cells. However, sarcoma of any grade may come back again if it is not completely treated. Rhabdomyosarcoma. If rhabdomyosarcoma is in an arm or leg, and all of the tumor can be removed, chemotherapy usually follows surgery
  5. Cancer is the leading cause of death in dogs. 47% of deaths in dogs are related to cancer, especially when the dog is over 10 years old. There are many types of cancer that your dog can develop, soft tissue sarcoma is one of them. Soft tissue sarcomas (STS) are a variety of tumors from the mesenchymal cells
  6. grading of tumors. Several studies have been performed that evaluate the diagnostic and grading performance of 18F-FDG PET for soft-tissue sarcoma, but each study has had a limited sample size. Therefore, we undertook a comprehensive meta-analysis of the evidence. Methods: Relevant studies were iden-tified from MEDLINE and EMBASE. Diagnostic.
  7. Recommendations for Developing a Grading Scheme for Canine Soft Tissue Sarcomas The original paper describing the development of the grading scheme used for human soft tissue sarcomas might serve as an example of how a canine grading scheme can be established. Trojani and colleagues evaluated seven characteristics: tumo

Soft tissue sarcoma Radiomics Tumor grading MRI Risk stratification Biomarker 1. Introduction Soft tissue sarcomas (STS) constitute rare malignant diseases [1]. In contrast to manyother malignanttumors, treatment decisions strongly depend on pre-therapeutic tumor grading [2] After soft tissue sarcoma is diagnosed, a series of tests are used to investigate the extent of the cancer and to see whether it has spread to other parts of the body from where it started. Staging is a way of recording the size, aggressiveness and growth of a cancer, and determining the plan for treatment

18 F-FDG PET; meta-analysis; soft-tissue sarcoma; PET using 18 F-FDG is increasingly being established as a key imaging technique in the diagnosis, grading, staging, and assessment of response to therapy of diverse types of tumors (1,2). 18 F-FDG PET is considered as a potentially major advance in clinical practice, because it may offer information about not only the anatomic extent but also. In this present study we have attempted to grade soft tissue sarcomas on fine‐needle aspiration cytology (FNAC) material and then subsequently correlated our findings on histology section. A total of 44 cases of primary soft tissue sarcomas (STS) were graded and correlated with the subsequent histopathology sections. FNAC successfully diagnosed 40 cases and four cases were reported as benign. Soft Tissue Sarcoma Incidence Grade is part of the staging system. TNM Staging System (2010) Stage IA Stage IB G1 T1a/b N0 M0 G1 T2a/b N0 M0 Low grade, small Low grade, large Stage IIA Stage IIB G2,3 T1a/b N0 M0 G2 T2a/b N0 M0 Moderate/high grade, smal

Treatment of Soft Tissue Sarcomas, by Stag

The purpose of the current study is to compare the diagnostic accuracy of MR imaging in grading and characterization of soft tissue tumors (STT) of the initial report made by the referring radiologist in a large community hospital and the second opinion report made by the experts of the BSTNR Soft tissue - Myxoinflammatory fibroblastic sarcoma Rare, low grade sarcoma of the distal extremities with prominent myxoid stroma, mixed inflammation, virocyte-like cells, pseudo lipoblast-like cells and emperipolesi

Pathology Outlines - Epithelioid sarcoma

Histologic grading has been considered the most important prognostic factor for soft tissue sarcomas. Several grading systems have been proposed based on the assessment of morphologic features in heterogeneous groups of sarcomas. Currently, the French Federation of Cancer Centers (FNCLCC) and the National Cancer Institute (NCI) grading systems. Postoperative radiotherapy is considered to be the standard approach for nearly all intermediate or high-grade soft tissue sarcomas (see Table 3). This allows preservation of function with similar local control rates and survival to radical resection (i.e., compartmental excision/amputation) . The majority of patients with low grade tumours.

  1. Soft Tissue Sarcomas. Soft tissue sarcomas are cancerous tumors that begin in the soft tissues of the body such as muscles, fat, joints, nerves, and blood vessels. They are not common, accounting for about 1% of all cancers. It is estimated that there are approximately 30 new cases of soft tissue sarcoma per year among every one million people
  2. There are 50 different types of soft tissue sarcomas, which can develop in many different locations and tissues within the body. Because of this great variability among soft tissue sarcomas, recommended treatment options will vary, depending upon the stage, grade, type and location of the tumor. Thus, developing an individualized treatment plan with your Cancer Treatment Centers of America.
  3. Adult soft tissue sarcoma treatment depends on the tumor grade and location. It can form almost anywhere in the body, but is most common in the head, neck, arms, legs, trunk, and abdomen. Find out about risk and genetic factors, symptoms, tests to diagnose, prognosis, staging, and treatment for soft tissue sarcoma

Our sarcoma local recurrence nomogram is a tool designed to predict the likelihood of soft tissue sarcoma returning at the site of initial surgery after the tumor is removed through limb-sparing surgery if the patient does NOT receive radiation. The probability of local recurrence is calculated for both three years and five years after surgery Low-grade soft tissue sarcomas are linked with a better prognosis because they are less likely to spread (metastasize) or come back (recur) than high-grade sarcomas. How deep the tumour is Soft tissue tumours close to the surface of the body (superficial tumours) have a better prognosis than tumours that are growing deep within the body The type of soft tissue sarcoma you have tells you the type of cell that the cancer started in. Knowing this helps your doctor decide which treatment you need. Stages and grades. Staging means how big the cancer is and whether it has spread. Grading means how abnormal the cancer cells look under a microscope

Understanding How Soft Tissue Sarcoma Is Staged and Graded

High cancer grade - Grade 3 soft tissue sarcomas have a 46-50% rate of cancer spread to other organs - most commonly the lungs - worsening the prognosis Overall, the median survival time for dogs with soft tissue sarcomas is 1400 days, with about 33% of dogs eventually dying from tumour-related causes In the case of soft tissue sarcoma, grading is of vital importance for determining prognosis. The staging and grading, along with the patient's performance status—how well they can perform daily tasks and tolerate treatments—and other factors help inform treatment decisions and the overall prognosis Soft tissue sarcoma is a rare type of cancer that begins in the tissues that connect, support and surround other body structures. This includes muscle, fat, blood vessels, nerves, tendons and the lining of your joints. More than 50 subtypes of soft tissue sarcoma exist. Some types are more likely to affect children, while others affect mostly. A soft tissue sarcoma is graded as low-grade or high-grade malignancy on histopathology. High-grade soft tissue sarcomas can be moderately differentiated, poorly differentiated, or undifferentiated. Key Points Histopathologic considerations • According to the WHO, more than 50 histologic subtypes of soft tissue sarcomas exist Stage 3: Stage 3 is divided into 3A or 3B based on the size of the tumor, the lymph node involvement or grade (based on the type of soft tissue sarcoma). Stage 4 (metastatic): The tumor has spread to the lymph nodes in the extremities or to other parts of the body (for example, the lungs). Bone sarcoma stages

Soft tissue tumor

Recognizing this, in 2002, the WHO classification of soft tissue sarcomas divided many of the subtypes that made up MFH into distinct subtypes of soft tissue sarcoma. However, despite advances in diagnostics, there is still a group of soft tissue sarcomas that have no distinct line of differentiation to classify them more specifically High-grade and mid-grade tumors usually grow and spread more quickly than low-grade tumors. Because soft tissue sarcoma can be hard to diagnose, the tissue sample should be checked by a pathologist who has experience in diagnosing soft tissue sarcoma. One or more of the following laboratory tests may be done to study the tissue samples Fingerprint Dive into the research topics of 'Federation Nationale des Centers de Lutte Contre le Cancer grading of soft tissue sarcomas on needle core biopsies using surrogate markers'. Together they form a unique fingerprint. Large-Core Needle Biopsy Medicine & Life Science Current utilities of imaging in grading musculoskeletal soft tissue sarcomas. Eur J Radiol. 2016; 85(7):1336-44 (ISSN: 1872-7727) Fisher SM; Joodi R; Madhuranthakam AJ; Öz OK; Sharma R; Chhabra A. The care of patients with musculoskeletal malignancies has increasingly become a multidisciplinary function *Adult soft tissue sarcoma facts written by Melissa Conrad Stöppler, MD. A sarcoma is a cancer that forms in soft tissues of the body such as muscles, fat tissue, blood vessels, tendons, and nerves. Tumors of these tissues can also be benign (non-cancerous).; There are over 50 different kinds of soft tissue sarcoma

Grading soft tissue sarcoma - Canadian Cancer Societ

The WHO Classification of Tumours of Soft Tissue and BoneCanine Soft-Tissue Sarcomas in Dogs | PetHelpfulSoft Tissue Sarcoma | Oncohema KeySoft tissue sarcomaCurrent role of FDG-PET in Bone and Soft tissue tumorsApproach to Soft Tissue Tumor in Upper Extremity

Grade 1 and 2 soft tissue sarcomas have low metastatic potential (<15-20%) and grade III tumors have high metastatic potential (up to 40-50%). Mitotic index (aka mitotic count) is predictive of survival. To maximize the likelihood of a positive outcome, soft tissue sarcomas should be widely and deeply resected to achieve clean margins Treatment for soft tissue sarcoma depends on the location of the tumor and therefore varies from patient to patient. Treatment can be as simple as surgically removing the tumor through a small incision to extensive surgery and aggressive chemotherapy, with or without radiation. The course of therapy is generally determined by the tumor type or. Soft tissue sarcoma is a form of cancerous tumor. The sarcoma is originated in the soft tissues of the body. The vital soft tissues are the tissue which performs the action of connecting the various body parts. The major soft tissues in the body are muscles, nerves, blood vessels, fat and tendons. The synovial tissues are also considered as the.